Monitoring Dosage in Transdermal Patches

A 36″ wide diffuse transmission light source developed by MSV was paired with a hyperspectral camera to monitor the manufacturing process of transdermal patches.

A diagram of a manufacturing line showing the placement of a hyperspectral camera and light source for monitoring product composition.

Challenge

A Fortune 500 pharmaceutical company producing transdermal patches was interested in monitoring the composition of the entire wide production web in its roll-roll manufacturing lines.

Solution

For the process monitoring a Stirling-cooled SWIR hyperspectral camera (1000-2500 nm) coupled with a 36” wide diffuse transmission light source was developed. A line-light with 24 halogen lamps in a row provided a diffuse light for the transmission measurement through the production film. The special software was able to predict the unit dose of all products die-cut downstream from the web. The CFR compliant software developed controls the camera, collects dark readings periodically, and is also able to calculate thickness and composition in real-time and to communicate with the production floor OPC server, saving the appropriate witness data and informing the operator if the set parameters reach warning or alarm levels.